- Trial statusClosed
- Study email firstname.lastname@example.org
- Chief InvestigatorProfessor Neil Poulter
- Project managerMs Gaia Kiru
- SponsorImperial College London
- ISRCTN numberISRCTN51383267
Aortic Aneurysmal Regression of Dilation : Value of Ace-inhibition on RisK
Design and Objective
To investigate the hypothesis that an ACE-inhibitor reduces abdominal aortic aneurysm (AAA) growth rate in a 3-arm randomised controlled pilot trial: The three interventions are ACE-inhibition with perindopril versus equivalent blood pressure reduction with amlodipine (a calcium channel blocker) versus placebo.
Key inclusion criteria
1)Willing and able to give written informed consent 2) Men or women, aged at least 55 years 3)With AAA 3 to 5.4 cm in diameter by internal or external measurement according to ultrasound AND 4) A systolic BP <150mmHg (unless they require and are already receiving an ACE-inhibitor or amlodipine 10mg daily).
Study Disclaimer Statement
Funding/publication acknowledgement This project was funded by the HTA Programme (project number 08/109/02 ).