ICTUImperial Clinical Trials Unit

Welcome to Imperial Clinical Trials Unit (ICTU)

This website is intended for commercial trial sponsors engaged in the area of pharmaceuticals, medical devices or diagnostic devices

Clinical Trials Search


CurrentAll Trials


Trial Details

  • Trial statusClosed
  • Study email contactaardvark@imperial.ac.uk
  • Chief InvestigatorProfessor Neil Poulter
  • Project managerMs Gaia Kiru
  • SponsorImperial College London
  • ISRCTN numberISRCTN51383267
  • Phase2

Aortic Aneurysmal Regression of Dilation : Value of Ace-inhibition on RisK

Design and Objective

To investigate the hypothesis that an ACE-inhibitor reduces abdominal aortic aneurysm (AAA) growth rate in a 3-arm randomised controlled pilot trial: The three interventions are ACE-inhibition with perindopril versus equivalent blood pressure reduction with amlodipine (a calcium channel blocker) versus placebo.

Key inclusion criteria

1)Willing and able to give written informed consent 2) Men or women, aged at least 55 years 3)With AAA 3 to 5.4 cm in diameter by internal or external measurement according to ultrasound AND 4) A systolic BP <150mmHg (unless they require and are already receiving an ACE-inhibitor or amlodipine 10mg daily).

Study Disclaimer Statement

Funding/publication acknowledgement This project was funded by the HTA Programme (project number 08/109/02 ).