IP4 – CHRONOS
Comparative Health Research Outcomes of Novel Surgery in Prostate Cancer
Design and Objective
Two linked open label, multicentre RCTs with choice of A or B dependent on physician and patient equipoise. CHRONOS-A: Two arm RCT to evaluate progression free survival rates of Focal Therapy (FT) compared to radical therapy (radiotherapy or surgery) in prostate cancer treatment. CHRONOS-B: Multi-Arm Multi-Stage RCT to evaluate failure free survival rates of FT alone compared to FT combined with other therapies.
Key inclusion criteria
Men over 18 years old with a diagnosis of medium risk prostate cancer or low risk cancer proven on biopsy. Participants should have an interest in undergoing Focal Therapy as a treatment for prostate cancer and be fit to undergo Radical Therapy or Focal Therapy without any previous prostate cancer treatments.